RT Book, Section
A1 Morgan, David N.
A1 Davis, Jennifer J.
A2 Johnson, Ken B.
SR Print(0)
ID 1103964162
T1 Anticoagulant and Antiplatelet Drugs
T2 Clinical Pharmacology for Anesthesiology
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071736169
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1103964162
RD 2024/04/24
AB Anticoagulants  are  widely  used  in  the  perioperative  period.  The  anesthesia  consultant  must  have  an  understanding  of  their  pharmacology  and  the  implications  of  their  use  in  a  myriad  of  clinical  scenarios.  Intricate  and  complex  processes  that  influence  coagulation  and  anticoagulation  are  always  in  a  dynamic  state  of  equilibrium.  The  balance  is  shifted  one  way  or  the  other  by  various  disease  states,  medications,  or  perioperative  events  (ie,  hemodilution  with  aggressive  resuscitation).  Anesthesiologists  are  often  called  upon  to  find  a  reasonable  balance  between  anticoagulation  and  hemostasis  in  a  variety  of  circumstances,  such  as  during  procedures  associated  with  blood  loss  in  patients  at  risk  for  arterial  thrombotic  events  or  when  managing  postoperative  neuraxial  analgesia  in  patients  at  high  risk  for  deep  vein  thrombosis.  The  focus  of  this  chapter  is  on  elements  of  anticoagulant  clinical  pharmacology  that  are  important  for  anesthesiologists  to  understand.  Anticoagulation  drugs  represent  a  rapidly  expanding  field,  with  many  novel  agents  in  various  stages  of  testing  and  approval.  However,  this  chapter  will  be  confined  to  classes  of  anticoagulants  and  antiplatelets  in  clinical  use.  A  summary  of  these  drugs  is  presented  in  Table  16–1.