RT Book, Section A1 Johnson, Ken B. A1 Tams, Carl A2 Johnson, Ken B. SR Print(0) ID 1103963306 T1 Importance and Limitations of Simulation in Clinical Pharmacology T2 Clinical Pharmacology for Anesthesiology YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071736169 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1103963306 RD 2025/05/21 AB Anesthesiologists use many potent drugs either as single agents or in combination. Each of these drugs has a unique profile in terms of how their concentrations and effects change over time and how they interact with other drugs. Although the basic features of anesthetic drugs are well established, the time course of how the drugs behave, especially in combination with other drugs, is complex and difficult to predict. Anesthesiologists rely on experience and training to formulate dosing regimens, yet they can be confounded by the dynamic changes encountered in the operating room and intensive care unit.