RT Book, Section
A1 Johnson, Ken B.
A1 Egan, Talmage D.
A2 Johnson, Ken B.
SR Print(0)
ID 1103962917
T1 Pharmacokinetics, Biophase, and Pharmacodynamics and the Importance of Simulation
T2 Clinical Pharmacology for Anesthesiology
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071736169
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1103962917
RD 2024/10/03
AB When  selecting  an  anesthetic,  anesthetists  often  consider,  among  others,  the  questions  presented  in  Table  1–1.  To  answer  these  questions,  anesthetists  turn  to  textbooks,  journal  articles,  and  drug  package  inserts.  These  resources  provide  dosing  recommendations  (ie,  bolus  doses  and  infusion  rates)  and  important  features  of  anesthetic  drugs  but  often  fall  short  of  providing  useful  answers.  Anesthetists  therefore  rely  on  years  of  training  and  experience  to  formulate  the  correct  dose  and  safely  administer  it.  Experienced  anesthetists  develop  a  sense  of  how  individual  drugs  behave  and  can  easily  tailor  them  to  meet  the  needs  of  their  patients.  For  example,  anesthetists  have  a  good  “feel”  for  what  a  3-mL  (150  mcg)  intravenous  bolus  of  fentanyl  will  accomplish  in  a  healthy  adult  and  can  accurately  predict  the  onset  and  duration  of  analgesic  effect.