RT Book, Section A1 Winn, Andrew A1 Freeman, Brian S. A2 Freeman, Brian S. A2 Berger, Jeffrey S. SR Print(0) ID 1102569882 T1 Hepatic Drug Metabolism and Excretion T2 Anesthesiology Core Review: Part One Basic Exam YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071821377 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1102569882 RD 2024/04/20 AB The liver is the primary organ involved in drug metabolism. Under normal conditions, it receives approximately 1.2-1.4 L of blood per minute, which is roughly 25% of cardiac output. Seventy five percent of blood arriving to the liver is from the portal vein, whereas the remaining 25% is from the hepatic arteries.