RT Book, Section
A1 Winn, Andrew
A1 Freeman, Brian S.
A2 Freeman, Brian S.
A2 Berger, Jeffrey S.
SR Print(0)
ID 1102569179
T1 Carbon Dioxide Transport
T2 Anesthesiology Core Review: Part One Basic Exam
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071821377
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1102569179
RD 2024/04/24
AB In  the  human  body,  carbon  dioxide  (CO2)  is  a  metabolic  waste  product  of  aerobic  metabolism.  Specifically,  two  catabolic  processes,  pyruvate  decarboxylation  and  the  Kreb’s  cycle,  both  of  which  occur  in  the  mitochondria  of  cells,  produce  CO2.  As  a  result  of  these  processes,  the  concentration  of  CO2  increases  proportionally  to  metabolic  activity  within  tissues,  leading  to  an  increased  partial  pressure  of  carbon  dioxide  (Pco2).  This  pressure  gradient  drives  CO2,  a  highly  lipid-soluble  molecule,  out  of  tissues,  across  cell  membranes,  and  into  the  blood  of  systemic  capillaries.  Once  it  has  diffused  into  the  capillaries,  CO2  is  transported  to  the  lungs  by  three  mechanisms.