RT Book, Section
A1 Nguyen, Vinh
A2 Freeman, Brian S.
A2 Berger, Jeffrey S.
SR Print(0)
ID 1102566954
T1 Minimum Alveolar Concentration
T2 Anesthesiology Core Review: Part One Basic Exam
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071821377
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1102566954
RD 2024/04/23
AB The  concept  of  minimum  alveolar  concentration  (MAC)  was  first  introduced  by  Dr.  Edmund  Eger  in  1965.  Prior  to  this  time,  there  was  no  accurate  way  to  measure  the  anesthetic  potencies  or  adequate  dosing.  Earlier  methods  focused  on  the  assessment  of  clinical  signs,  such  as  pupil  diameter,  eyelid  reflex,  and  lacrimation  during  the  different  stages  of  anesthesia.  Compared  to  the  limitations  associated  with  these  signs,  the  principle  of  MAC  targets  a  single  clinical  end  point:  immobility  in  response  to  surgical  stimulus.  MAC  is  defined  as  the  minimum  alveolar  concentration  of  inhaled  anesthetic  at  sea  level  required  to  suppress  movement  to  a  surgical  incision  in  50%  of  the  patients.  It  is  often  referred  to  as  the  ED50  for  immobility,  MAC-movement,  or  median  alveolar  concentration.