RT Book, Section
A1 Vashishta, Rishi
A1 Berrigan, Michael J.
A2 Freeman, Brian S.
A2 Berger, Jeffrey S.
SR Print(0)
ID 1102566806
T1 Drug Tolerance and Tachyphylaxis
T2 Anesthesiology Core Review: Part One Basic Exam
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071821377
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1102566806
RD 2024/04/19
AB Physiologic  tolerance,  or  desensitization,  is  well  described  in  clinical  pharmacology.  It  is  defined  by  progressively  diminished  response  to  drug  at  a  certain  dose  following  repeated  exposure,  and  requiring  increasing  dosages  to  achieve  the  desired  effect  on  subsequent  administrations.  Drug  tolerance  refers  to  changes  in  the  potency  (higher  effective  dose  required),  the  effectiveness  (decreased  maximal  effect),  or  both  aspects  of  the  drug.