RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Marciniak, Bruno A1 Dalens, Bernard J. SR Print(0) ID 58084033 T1 Protein C Deficiency T2 Syndromes: Rapid Recognition and Perioperative Implications YR 2006 FD 2006 PB The McGraw-Hill Companies PP New York, NY SN 9780071354554 LK accessanesthesiology.mhmedical.com/content.aspx?aid=58084033 RD 2024/10/15 AB Congenital or acquired control of the clotting mechanism resulting in a widespread thrombotic tendency. Protein C is a vitamin K-dependent serine protease zymogen that selectively inhibits factors Va and VIII:C in human plasma, and thus has an important anticoagulant role. It is associated with an increased tendency to thrombosis. It is either inherited or acquired: bacterial sepsis (especially of meningococcal origin), hepatic disease, disseminated intravascular coagulation, l-asparaginase therapy, nephrotic syndrome, conditioning therapy in bone marrow transplantation, warfarin-induced skin lesions.