RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Marciniak, Bruno
A1 Dalens, Bernard J.
SR Print(0)
ID 58076158
T1 Miller-Dieker Lissencephaly Syndrome
T2 Syndromes: Rapid Recognition and Perioperative Implications
YR 2006
FD 2006
PB The McGraw-Hill Companies
PP New York, NY
SN 9780071354554
LK accessanesthesiology.mhmedical.com/content.aspx?aid=58076158
RD 2024/04/18
AB Malformation  of  the  cerebral  cortex  with  abnormal  facies.  Classic  lissencephaly,  also  known  as  lissencephaly  type  I,  is  a  brain  malformation  that  may  occur  as  an  isolated  abnormality  (isolated  lissencephaly  sequence)  or  in  association  with  certain  underlying  syndromes  (e.g.,  Miller-Dieker  syndrome,  Norman-Roberts  syndrome).  The  condition  is  characterized  by  agyria  or  pachygyria  of  the  gyri  of  the  cerebral  cortex,  causing  the  brain's  surface  to  appear  unusually  smooth.  In  infants  with  classic  lissencephaly,  microcephaly  is  usually  present.  Other  clinical  features  include  seizures,  severe  or  profound  mental  retardation,  feeding  difficulties,  growth  retardation,  and  impaired  motor  functions.