RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Marciniak, Bruno A1 Dalens, Bernard J. SR Print(0) ID 58062201 T1 Alkaptonuria (AKU) T2 Syndromes: Rapid Recognition and Perioperative Implications YR 2006 FD 2006 PB The McGraw-Hill Companies PP New York, NY SN 9780071354554 LK accessanesthesiology.mhmedical.com/content.aspx?aid=58062201 RD 2024/09/11 AB Deficiency of homogentisic acid oxidase leads to discoloration and staining of tissues. Sudden dark urine should alert the clinician of the possible presence of homogentisic acid. Valvular heart disease and myocardial ischemia may occur in adults.