RT Book, Section A1 Corripio, Manuel A2 Atchabahian, Arthur A2 Gupta, Ruchir SR Print(0) ID 57261431 T1 Chapter 73. Ophthalmology T2 The Anesthesia Guide YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-176049-2 LK accessanesthesiology.mhmedical.com/content.aspx?aid=57261431 RD 2024/04/19 AB Regulation of intraocular pressure (IOP). Normal intraocular pressure: 12–20 mm HgClinical pearl: Pressure from a tightly fitted mask, improper prone position or retrobulbar hemorrhage can lead to ↑ IOPMechanisms for the decrease of IOP: a drop in BP reduces choroidal volume, relaxation of the extraocular muscles (EOM) lowers wall tension, and papillary constriction facilitates aqueous outflowClinical pearl: Succinylcholine ↑ IOP by 5–10 mm Hg for 5–10 minutes, through prolonged contracture of the EOM. This may cause:Extrusion of ocular contents through an open surgical or traumatic woundAbnormal forced duction test for 20 minutes (test used in strabismus surgery)The oculocardiac reflex:Pathway: Afferent trigeminal nerve (V1)/Efferent vagus nerve (X)Most common scenarios: pediatric patients, strabismus surgerySymptoms/Signs: Cardiac dysrhythmias ranging from bradycardia to ventricular ectopy to sinus arrest. In awake patients, somnolence and nauseaPrevention:Anticholinergic medication. IV is more effective than IMRetrobulbar block and/or deep inhalation anesthesia may also helpLocal infiltration by surgeonManagement:Immediately notification of surgeon and temporary cessation of surgical stimulus until hemodynamic stabilityConfirm adequate ventilation, oxygenation, and depth of anesthesiaIV atropine (10 mcg/kg) if hemodynamic instabilityIf more than one episode, infiltration of the rectus muscle with local anestheticIntraocular gas expansion:The surgeon may inject air or gas into the posterior chamber to flatten a detached retina and allow better healingThe air bubble is usually absorbed in 5 days by diffusionIf the patient is breathing nitrous oxide (N2O) the bubble will increase in size → ↑IOPN2O is 35 times more soluble than nitrogen (major component in air) in bloodSulfur hexafluoride (SF6) is an inert gas that is less soluble in blood than nitrogen, and less soluble than N2O. It has a duration of action of 10 daysBubble size doubles within 24 hours after injection because nitrogen from air enters the bubble more rapidly than the SF6 diffuses into the bloodstreamUnless high volumes of SF6 are injected, the slow bubble expansion will not increase IOPHowever, if a patient is breathing N2O, the bubble will rapidly increase in size and ↑ IOPN2O should be stopped at least 15 minutes before the injection of air and should be avoided until at least 5 days after the injection of air and 10 days after the injection of SF6Systemic side effects of ophthalmic drugs: