RT Book, Section
A1 Lodato, Robert F.
A2 Tobin, Martin J.
SR Print(0)
ID 57075902
T1 Chapter 45. Oxygen Toxicity
T2 Principles and Practice of Mechanical Ventilation, 3e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-173626-8
LK accessanesthesiology.mhmedical.com/content.aspx?aid=57075902
RD 2024/10/14
AB The  importance  of  the  physiology  and  toxicology  of  oxygen  (O2)  breathing  have  increased  in  recent  years.  The  past  25  years  have  witnessed  a  remarkable  upsurge  of  knowledge  and  interest  in  “oxidative  stress”  throughout  all  of  biology.  The  use  of  O2  continues  to  grow,  from  critically  ill  to  ambulatory  patients  and  even  to  recreational  use  at  “oxygen  bars.”1  Recent  advances  in  patient  care  have  refocused  attention  on  the  optimum  use  of  O2.  For  example,  currently,  strategies  to  protect  the  lung  from  mechanical  injury  during  mechanical  ventilation  emphasize  the  use  of  lower  tidal  volumes.  But  such  strategies  may  impair  gas  exchange,  resulting  in  higher  requirements  for  inspired  O2  fraction  (FIO2).2