RT Book, Section
A1 Leatherman, James W.
A2 Tobin, Martin J.
SR Print(0)
ID 57070714
T1 Chapter 30. Mechanical Ventilation for Severe Asthma
T2 Principles and Practice of Mechanical Ventilation, 3e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-173626-8
LK accessanesthesiology.mhmedical.com/content.aspx?aid=57070714
RD 2024/04/16
AB It  is  estimated  that  6000  to  10,000  patients  require  mechanical  ventilation  for  acute  asthma  in  the  United  States  each  year.1  Asthma  exacerbations  that  lead  to  mechanical  ventilation  typically  progress  over  1  or  more  days,  with  viral  infections  being  the  most  common  etiology  (Table  30-1).2  Airways  typically  show  extensive  mucous  plugging  and  eosinophilic  infiltration  with  edema,  explaining  the  often  limited  immediate  response  to  bronchodilators.3  Approximately  20%  of  patients  experience  a  more  explosive  onset,  with  attacks  occurring  over  minutes  to  hours.2–4  The  precise  cause  of  “sudden  asphyxial”  asthma  is  not  always  apparent,  but  recognized  triggers  include  aeroallergens,  nonsteroidal  antiinflammatory  agents,  airway  irritants,  and  emotional  distress.2,4  Rapid-onset  attacks  are  characterized  by  profound  bronchospasm  with  minimal  mucous  plugging,  explaining  both  their  sudden  onset  and  rapid  resolution.3