RT Book, Section A1 Lucangelo, Umberto A1 Nahum, Avi A1 Blanch, Lluis A2 Tobin, Martin J. SR Print(0) ID 57068116 T1 Chapter 22. Transtracheal Gas Insufflation, Transtracheal Oxygen Therapy, Emergency Transtracheal Ventilation T2 Principles and Practice of Mechanical Ventilation, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-173626-8 LK accessanesthesiology.mhmedical.com/content.aspx?aid=57068116 RD 2024/10/13 AB Clinical evidence highlights the importance of limiting airway pressure during mechanical ventilation. In addition, experimental results suggest the importance of avoiding lung overdistension and cyclic end-expiratory airspace collapse and reexpansion, indicating that both phenomena promote mechanical damage and release of inflammatory mediators.1–3 Unfortunately, interventions that can attenuate the structural insult caused by mechanical ventilation, such as the use of low tidal volume, high positive end-expiratory pressure, and reduced respiratory rate, can limit total minute ventilation.4,5 In this context, transtracheal oxygen therapy and tracheal gas insufflation (TGI) could have a role as adjuncts to mechanical ventilation.6–10