RT Book, Section A1 Gadsden, Jeff A2 Hadzic, Admir SR Print(0) ID 55900224 T1 Chapter 2. Local Anesthetics: Clinical Pharmacology and Rational Selection T2 Hadzic's Peripheral Nerve Blocks and Anatomy for Ultrasound-Guided Regional Anesthesia, 2e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-154963-9 LK accessanesthesiology.mhmedical.com/content.aspx?aid=55900224 RD 2024/03/29 AB Local anesthetics (LAs) prevent or relieve pain by interrupting nerve conduction. They bind to specific receptor sites on the sodium (Na+) channels in nerves and block the movement of ions through these pores. Both the chemical and pharmacologic properties of individual LA drugs determine their clinical properties. This chapter discusses the basics of the mechanism of action of LAs, their clinical use, and systemic toxicity prevention and treatment.