RT Book, Section A1 Miller, Timothy E. A2 Barbeito, Atilio A2 Shaw, Andrew D. A2 Grichnik, Katherine SR Print(0) ID 56784704 T1 Chapter 14. Extrapleural Pneumonectomy T2 Thoracic Anesthesia YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-162566-1 LK accessanesthesiology.mhmedical.com/content.aspx?aid=56784704 RD 2023/03/20 AB In an extrapleural pneumonectomy the lung is removed en bloc, together with parietal and visceral pleura, ipsilateral hemidiaphragm and pericardium, as well as mediastinal lymph nodes.The operation is now reserved almost exclusively for the treatment of mesothelioma. A recent randomized control trial showed no improved survival in patients treated with surgery in the context of trimodal therapy.2-10% of individuals with prolonged asbestos exposure will develop mesothelioma, but more than 80% of mesothelioma patients have a history of exposure to asbestos.The major anesthetic issues are significant blood loss, hemodynamic instability, difficult fluid therapy, risk of cardiac herniation and high probability of dysrhythmias.