RT Book, Section
A1 Hough, Stuart W.
A1 Kanner, Ronald M.
A2 Warfield, Carol A.
A2 Bajwa, Zahid H.
SR Print(0)
ID 3417002
T1 Chapter 44. Cancer Pain Syndromes
T2 Principles & Practice of Pain Medicine, 2e
YR 2004
FD 2004
PB The McGraw-Hill Companies
PP New York, NY
SN 9780071443494
LK accessanesthesiology.mhmedical.com/content.aspx?aid=3417002
RD 2023/09/24
AB Pain  in  cancer  patients  has  numerous  possible  causes.  The  vast  majority  of  pain  syndromes  are  caused  by  direct  tumor  involvement  of  pain-sensitive  structures,  a  smaller  number  are  treatment-related,  and  fewer  than  10%  are  unrelated  to  the  cancer.  Metastatic  disease  may  invade  bone,  obstruct  a  hollow  viscus,  and  compress  nerve  or  spinal  cord.  Radiation  treatment  may  cause  fibrosis  of  nerve  or  spinal  cord.  Chemotherapeutic  agents  may  cause  peripheral  neuropathy,  aseptic  bone  necrosis,  and  predispose  to  painful  opportunistic  infections.  Surgical  treatment  leads  to  acute  postoperative  pain,  and  may  cause  deafferentation  pain  if  major  nerves  or  nerve  plexi  are  cut.  In  any  given  patient,  one  or  more  of  these  factors  may  be  in  play,  and  more  than  50%  of  cancer  patients  with  pain  have  more  than  one  source  of  pain.1