RT Book, Section
A1 Bigatello, Luca M.
A1 Hellman, Judith
A1 Beutler, Sascha
A1 Zapol, Warren M.
A2 Longnecker, David E.
A2 Brown, David L.
A2 Newman, Mark F.
A2 Zapol, Warren M.
SR Print(0)
ID 56651625
T1 Chapter 73. The Pathophysiology of Critical Illness
T2 Anesthesiology, 2e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-178513-6
LK accessanesthesiology.mhmedical.com/content.aspx?aid=56651625
RD 2024/04/20
AB Acute  injuries  of  various  etiologies  (eg,  trauma,  infection,  shock,  etc)  cause  immediate  local  and  systemic  physiologic  responses  involving  all  major  organ  systems.The  timing  and  intensity  of  the  physiologic  response  to  injury  is  affected  by  the  severity  of  the  injury  as  well  as  host  factors.  An  initial  activation  of  the  proinflammatory  immune  responses  may  be  followed  by  late  immunosuppression.Nosocomial  infections  are  a  major  cause  of  death  of  critically  ill  patients  and  can  be  reduced  by  adopting  best  practices  of  infection  control.The  vascular  endothelium  is  a  major  organ  target  of  the  initial  response  to  injury  that  activates  vasomotor,  inflammatory,  and  procoagulant  cascades.Our  increased  understanding  of  the  molecular  biology  of  the  immune  response  to  injury  will  hopefully  lead  to  new  and  effective  therapies  that  may  include  oxygen  or  nitrogen  free-radical  scavenging,  mitochondrial  protection,  prevention  of  apoptosis,  and  enhancement  of  the  immune  response.