RT Book, Section
A1 Kato, Gregory J.
A1 Gladwin, Mark T.
A2 Hall, Jesse B.
A2 Schmidt, Gregory A.
A2 Wood, Lawrence D.H.
SR Print(0)
ID 2282146
T1 Chapter 108. Sickle Cell Disease
T2 Principles of Critical Care, 3e
YR 2005
FD 2005
PB The McGraw-Hill Companies
PP New York, NY
SN 9780071416405
LK accessanesthesiology.mhmedical.com/content.aspx?aid=2282146
RD 2022/05/28
AB Sickle  cell  disease  causes  a  chronic  hemolytic  anemia  associated  with  acute  and  chronic  vaso-occlusion.Baseline  hemodynamic  and  laboratory  values  in  patients  with  sickle  cell  disease  can  be  confused  with  sepsis.Serum  creatinine  levels  of  1  to  1.5  mg/dL  often  indicate  significant  renal  dysfunction.The  most  common  intensive  care  management  problems  in  patients  with  sickle  cell  disease  include  the  acute  chest  syndrome,  very  severe  anemia,  sepsis,  stroke,  priapism,  and  splenic  sequestration.Secondary  pulmonary  hypertension  occurs  in  30%  of  patients  with  sickle  cell  disease,  often  unrecognized.Red  cell  transfusion  is  an  important  treatment  for  most  patients  with  sickle  cell  disease  requiring  intensive  care  management.Rapid  exchange  transfusion  is  indicated  for  central  nervous  system  events,  serious  respiratory  disease,  or  multiorgan  failure.Transfusion  management  in  patients  with  sickle  cell  disease  requires  investigation  of  alloimmunization  history.Preoperative  red  cell  transfusion  and  detailed  supportive  care  are  advisable  for  significant  surgery  in  patients  with  sickle  cell  disease.