RT Book, Section A1 Scales, Damon C. A1 Granton, John T. A2 Hall, Jesse B. A2 Schmidt, Gregory A. A2 Wood, Lawrence D.H. SR Print(0) ID 2297315 T1 Chapter 90. The Transplant Patient T2 Principles of Critical Care, 3e YR 2005 FD 2005 PB The McGraw-Hill Companies PP New York, NY SN 9780071416405 LK accessanesthesiology.mhmedical.com/content.aspx?aid=2297315 RD 2022/05/28 AB The critical care of the transplant recipient requires a multidisciplinary approach.Although some generalizations can be made regarding the management of all transplant patients, organ-specific considerations based on the particular allograft transplanted are often much more important.Risks and benefits of immunosuppressive therapy must be balanced in transplant recipients. Though immunosuppressive drugs are essential to prevent allograft rejection, they also increase the risk of infection and neoplasm.All immunosuppressive drugs have side effects and many have important drug-drug interactions that must be recognized by the intensivist.Rejection of the allograft can be divided into three broad categories: hyperacute, acute, and chronic rejection.Infections can reactivate in an immunocompromised recipient who has been previously exposed. Alternatively, a naïve recipient may acquire an infection following the transplant of an organ from a seropositive donor.Infections in transplant recipients can progress rapidly and hence must be promptly recognized and appropriately treated.Often immunosuppressive therapy must be adjusted or withdrawn in the presence of severe infection.