RT Book, Section A1 Gadsden, Jeffrey A1 Hadzic, Admir A2 Hadzic, Admir SR Print(0) ID 3506646 T1 Chapter 58. Regional Anesthesia & Systemic Disease T2 NYSORA Textbook of Regional Anesthesia and Acute Pain Management YR 2007 FD 2007 PB The McGraw-Hill Companies PP New York, NY SN 9780071449069 LK accessanesthesiology.mhmedical.com/content.aspx?aid=3506646 RD 2021/03/01 AB Patients with coexisting severe systemic disease may be at a higher risk for perioperative complications related to surgery and administration of anesthesia. Regional anesthesia is often touted as beneficial in many patients who have pulmonary, cardiac, renal, and other disease. However, the physiologic changes that occur with various regional anesthesia techniques must be understood and viewed within the context of an individual patient's pathophysiology so that the technique benefits the patient fully and reduces the risk of complications from the patient' disease. This chapter focuses on the pathophysiology of several common systemic diseases frequently encountered by the regional anesthesiologist and discusses the interplay between common regional anesthesia techniques and patient disease.