RT Book, Section A1 Casati, Andrea A1 Putzu, Marta A2 Hadzic, Admir SR Print(0) ID 3503439 T1 Chapter 46. Multistimulation Techniques for Peripheral Nerve Blocks T2 NYSORA Textbook of Regional Anesthesia and Acute Pain Management YR 2007 FD 2007 PB The McGraw-Hill Companies PP New York, NY SN 9780071449069 LK accessanesthesiology.mhmedical.com/content.aspx?aid=3503439 RD 2024/04/25 AB Contrary to common, oversimplified representations by medical illustrators, the arrangement of peripheral nerves and plexuses is quite complex. Various tissue compartments contain connective tissue and fat; terminal branches of plexuses and nerves divide and separate frequently, and the different branches may run at some distance from one another. Accordingly, once injected at a particular site, the local anesthetic molecules have to diffuse through several barriers before reaching the nerves, the first barrier being the distance between the injection site and each branch.