RT Book, Section A1 Marhofer, Peter A1 Kapral, Stephan A1 Sala-Blanch, Xavier A2 Hadzic, Admir SR Print(0) ID 3502304 T1 Chapter 36. Three-in-One Block T2 NYSORA Textbook of Regional Anesthesia and Acute Pain Management YR 2007 FD 2007 PB The McGraw-Hill Companies PP New York, NY SN 9780071449069 LK accessanesthesiology.mhmedical.com/content.aspx?aid=3502304 RD 2024/04/19 AB The initial description of the 3-in-1 block was published by Winnie et al.1 in 1973 involving a small number of patients. The authors postulated that a block of the entire lumbar plexus can be accomplished by a single perivascular injection slightly distal to the inguinal ligament. Consequently, a single injection should result in anesthesia of the femoral, the lateral femoral cutaneous, and obturator nerves. Winnie et al.2,3 suggested that the underlying mechanism of this regional anesthetic technique should be a cephalad distribution of the local anesthetic along a fascial layer. This hypothesis, however, was never confirmed clinically. Moreover, an MRI study clarified the spread of local anesthetic after an inguinal injection of local anesthetic lateral to the femoral artery4,5 and concluded that the distribution of local anesthetic follows a lateral and slightly medial direction, but never a cephalad direction. Figures 36–1 and 36–2 illustrate that the spread of local anesthetic does not follow a proximal direction.