RT Book, Section A1 Freeman, Brian S. A1 Berger, Jeffrey S. SR Print(0) ID 1204770377 T1 Antithrombotic Drugs T2 Anesthesiology Core Review: Part One: BASIC Exam, 2nd Edition YR 2024 FD 2024 PB McGraw-Hill Education PP New York, NY SN 9781264285518 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1204770377 RD 2024/11/05 AB Obstruction of arterial or venous blood flow to vital vessels can have a dramatic impact on mortality and morbidity. Prior to thrombolytic agents, open surgical procedures were preformed to restore vessel patency and preserve vital organs. Antithrombotic agents are currently the mainstay therapy for achieving fibrinolysis during an acute ischemic event. Indications include acute myocardial infarction, ischemic stroke, deep venous thrombosis, pulmonary embolism, limb ischemia, and central line occlusion. Therefore, antithrombotic agents are used to target these blood clots directly using a catheter-directed thrombolysis (CDT) or a systemic approach to dissolve the existing obstruction.