RT Book, Section A1 Freeman, Brian S. A1 Berger, Jeffrey S. SR Print(0) ID 1204770165 T1 Hepatic Drug Metabolism and Excretion T2 Anesthesiology Core Review: Part One: BASIC Exam, 2nd Edition YR 2024 FD 2024 PB McGraw-Hill Education PP New York, NY SN 9781264285518 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1204770165 RD 2024/10/08 AB The liver is the primary organ involved in drug metabolism. Under normal conditions, it receives approximately 1.2–1.4 L of blood per minute, which is roughly 25% of cardiac output. Seventy five percent of blood arriving to the liver is from the portal vein, whereas the remaining 25% is from the hepatic arteries.