RT Book, Section A1 Freeman, Brian S. A1 Berger, Jeffrey S. SR Print(0) ID 1204768731 T1 Cerebral Protection T2 Anesthesiology Core Review: Part One: BASIC Exam, 2nd Edition YR 2024 FD 2024 PB McGraw-Hill Education PP New York, NY SN 9781264285518 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1204768731 RD 2024/10/07 AB The cerebral metabolic rate of O2 (CMRO2) is 3–3.8 mL/100 mg/min. Cerebral metabolism has two basic components: neuronal activity and cellular integrity. The brain depends on aerobic glucose metabolism; hence, large O2 demand consumes 20% of total body O2 to maintain neuronal activity for adenosine triphosphate (ATP) generation.