RT Book, Section
A1 Freeman, Brian S.
A1 Berger, Jeffrey S.
SR Print(0)
ID 1204766879
T1 Local Anesthetics
T2 Anesthesiology Core Review: Part One: BASIC Exam, 2<sup>nd</sup> Edition
YR 2024
FD 2024
PB McGraw-Hill Education
PP New York, NY
SN 9781264285518
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1204766879
RD 2024/10/13
AB Local  anesthetics  are  used  to  provide  intraoperative  regional  anesthesia  and  postoperative  analgesia.  Synthesized  from  the  coca  plant  in  1860,  cocaine  was  the  first  local  anesthetic  adapted  for  clinical  use.  Although  quite  effective,  cocaine  has  significant  limitations.  It  has  addictive  potential,  can  irritate  nerves,  and  is  still  the  only  local  anesthetic  capable  of  blocking  norepinephrine  reuptake  at  postganglionic  sympathetic  nerve  terminals.  The  introduction  of  lidocaine  in  1948  began  the  modern  era  of  local  anesthetics.