RT Book, Section A1 Kandiah, Prem A. A1 Nanchal, Rahul A1 Subramanian, Ram M. A2 Schmidt, Gregory A. A2 Kress, John P. A2 Douglas, Ivor S. SR Print(0) ID 1201809862 T1 Acute Liver Failure T2 Hall, Schmidt and Wood’s Principles of Critical Care, 5th Edition YR 2023 FD 2023 PB McGraw Hill PP New York, NY SN 9781264264353 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1201809862 RD 2023/12/10 AB KEY POINTSAcute liver failure is a syndrome with sudden loss of liver function characterized by transaminitis, coagulopathy, and encephalopathy in a patient without previous liver disease.Etiologies vary greatly; however, acetaminophen toxicity and viral hepatitis infections are among the most common.Shock, kidney failure, encephalopathy, and sepsis are common complications of acute liver failure.High-volume plasma exchange and continuous renal replacement therapy are interventions that are associated with improved survival.Aggressive supportive care at a center that performs liver transplantation optimizes patient outcomes.