RT Book, Section A1 Collison, Maggie A1 Galaydick, Jodi A1 Weber, Stephen G. A2 Schmidt, Gregory A. A2 Kress, John P. A2 Douglas, Ivor S. SR Print(0) ID 1201806371 T1 Gastrointestinal Infections and Clostridium Difficile T2 Hall, Schmidt and Wood’s Principles of Critical Care, 5th Edition YR 2023 FD 2023 PB McGraw Hill PP New York, NY SN 9781264264353 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1201806371 RD 2023/12/02 AB KEY POINTSIn addition to immunologic mechanisms, physical (motility), chemical (gastric acidity), and microbiologic (normal colonizing flora) factors normally protect the gastrointestinal tract against infection.Esophagitis, most commonly caused by Candida albicans or herpes simplex virus, may be underrecognized among patients in the intensive care unit.Infection with Helicobacter pylori may play a role in the pathogenesis of gastric stress ulceration among critically ill patients.The epidemiology and microbiology of diarrheal illness is significantly different among patients in the critical care unit than is observed in the community setting. Most infectious diarrhea in the ICU is hospital-acquired and is usually attributable to Clostridium difficile.A systematic approach to the critically ill patient with diarrhea includes consideration of pathogens that cause noninflammatory, inflammatory, and hemorrhagic diarrhea.