RT Book, Section A1 Daneman, Richard A1 Hammarlund-Udenaes, Margareta A1 Shusta, Eric V. A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193229282 T1 The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1193229282 RD 2024/03/28 AB AbbreviationsApo: apolipoproteinATP: adenosine triphosphateAUC: area under the concentration-time curveBBB: blood-brain barrierBCRP: breast cancer resistance proteinBCSFB: blood–cerebrospinal fluid barrierCSF: cerebrospinal fluidfu,brain: unbound fraction of drug in brain homogenatefu,plasma: unbound fraction of drug in plasmaFUS: focused ultrasoundIR: insulin receptorISF: interstitial fluidKp,uu,brain: partition coefficient of unbound drug in brain interstitial fluid to that in plasmaKp,uu,cell: partition coefficient of unbound drug between intracellular and interstitial fluidsLDLRf: low-density lipoprotein receptor familyMRP: multidrug resistance proteinPET: positron emission tomographyPS: permeability surface area productRMT: receptor-mediated transcytosisTf: transferrinTfR: transferrin receptorVu,brain: unbound volume of distribution in the brain; i.e., partitioning of total drug to that unbound in the brain interstitial fluid