RT Book, Section
A1 Zuraw, Bruce L.
A1 Christiansen, Sandra C.
A2 Brunton, Laurence L.
A2 Knollmann, Björn C.
SR Print(0)
ID 1194860222
T1 Histamine, Bradykinin, and Their Antagonists
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264258079
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1194860222
RD 2024/04/25
AB Histamine  is  an  endogenous  biogenic  amine  that  plays  a  role  in  the  immediate  allergic  response  and  is  an  important  regulator  of  gastric  acid  secretion.  More  recently,  a  role  for  histamine  as  a  modulator  of  neurotransmitter  release  in  the  central  and  peripheral  nervous  systems  has  emerged.  The  cloning  of  four  receptors  for  histamine  and  the  development  of  subtype-specific  receptor  antagonists  have  enhanced  our  understanding  of  the  physiological  and  pathophysiological  roles  of  histamine.  Competitive  antagonists  of  H1  receptors  are  used  therapeutically  in  treating  allergies,  urticaria,  anaphylactic  reactions,  nausea,  motion  sickness,  and  insomnia.  Antagonists  of  the  H2  receptor  are  effective  in  reducing  gastric  acid  secretion.