RT Book, Section
A1 Rothlin, Carla V.
A1 Gutkind, J. Silvio
A2 Brunton, Laurence L.
A2 Knollmann, Björn C.
SR Print(0)
ID 1193234400
T1 Immunosuppressants, Immunomodulation, and Tolerance
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264258079
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1193234400
RD 2024/04/18
AB This  chapter  reviews  the  components  of  the  immune  response  and  drugs  that  modulate  immunity  via  immunosuppression,  tolerance,  or  neutralization  of  cytokine  signaling.  Four  major  classes  of  immunosuppressive  drugs  are  discussed:  glucocorticoids,  calcineurin  inhibitors,  antiproliferative  and  antimetabolic  agents,  and  antibodies  or  small  molecules  that  target  cytokine  signaling.  While  there  are  similarities,  the  approach  to  the  use  of  immunosuppressant  drugs  in  transplant  rejection  has  evolved  separately  from  the  approaches  used  to  treat  autoimmune  disease  and  thus  is  presented  separately.