RT Book, Section A1 Wellstein, Anton A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193241431 T1 General Principles in the Pharmacotherapy of Cancer T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1193241431 RD 2024/10/15 AB Cancer pharmacology has changed dramatically during the recent past, with the improved understanding of cancer biology and an ever-expanding set of new drugs that target vulnerabilities in specific cancers. Effective treatments had been developed earlier for some fatal malignancies, including testicular cancer, lymphomas, and leukemia. Adjuvant chemotherapy and hormonal therapy can extend overall survival and prevent disease recurrence following surgical resection of localized breast, colorectal, and lung cancers. Chemotherapy is also employed as part of the multimodal treatment of locally advanced head and neck, breast, lung, and esophageal cancers; soft-tissue sarcomas; and pediatric solid tumors, thereby allowing for neoadjuvant surgery that is more limited and results in favorable outcomes (Chabner and Roberts, 2005).