RT Book, Section A1 Butterworth IV, John F. A1 Mackey, David C. A1 Wasnick, John D. SR Print(0) ID 1190607697 T1 Anesthesia for Patients with Kidney Disease T2 Morgan & Mikhail’s Clinical Anesthesiology, 7e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781260473797 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1190607697 RD 2024/03/29 AB KEY CONCEPTS The utility of a single serum creatinine measurement as an indicator of glomerular filtration rate (GFR) is limited in critical illness: The rate of creatinine production, and its volume of distribution, may be abnormal in the critically ill patient, and the serum creatinine concentration often does not accurately reflect GFR in the physiological disequilibrium of acute kidney injury (AKI). Creatinine clearance measurement is the most accurate method available for clinically assessing overall kidney function. Accumulation of morphine (morphine-6-glucuronide) and meperidine (normeperidine) metabolites may prolong respiratory depression in patients with kidney failure, and increased levels of normeperidine may promote seizure activity. Succinylcholine can be safely used in patients with kidney failure in the absence of hyperkalemia at the time of induction. Extracellular fluid overload from sodium retention, in association with increased cardiac demand imposed by anemia and hypertension, makes patients with end-stage kidney disease particularly prone to congestive heart failure and pulmonary edema. Delayed gastric emptying secondary to kidney disease–associated autonomic neuropathy may predispose patients to perioperative aspiration. Controlled ventilation should be considered for patients with kidney failure under general anesthesia. Inadequate spontaneous or assisted ventilation with progressive hypercarbia under anesthesia can result in respiratory acidosis that may exacerbate preexisting acidemia, lead to potentially severe circulatory depression, and result in dangerously increased serum potassium concentration. Correct anesthetic management of patients with renal insufficiency is as critical as management of those with frank kidney failure, especially during procedures associated with a relatively high incidence of postoperative kidney failure, such as cardiac and aortic reconstructive surgery. Intravascular volume depletion, sepsis, obstructive jaundice, crush injuries, and renal toxins, such as radiocontrast agents, certain antibiotics, angiotensin-converting enzyme inhibitors, and nonsteroidal anti-inflammatory drugs, are major risk factors for acute deterioration in kidney function and kidney failure. Kidney protection with adequate hydration and maintenance of renal blood flow is especially important for patients at high risk for perioperative AKI and kidney failure, such as those undergoing cardiac, major aortic reconstructive, and other surgical procedures associated with significant physiological trespass. The use of mannitol, low-dose dopamine infusion, loop diuretics, or fenoldopam for kidney protection is controversial and without proof of efficacy.