RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164087971 T1 Wermer Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164087971 RD 2024/03/29 AB Neoplastic disease characterized by tumors or hyperplasia of the parathyroid and pituitary glands and the islands of Langerhans (pancreas), with increased incidence of adrenocortical and thyroid disease. Hyperparathyroidism is present in more than 90% of affected patients. Asymptomatic hypercalcemia is the most common clinical manifestation. It is reported that 25% of patients consult for nephrolithiasis or nephrocalcinosis. Pituitary tumors occur in 15 to 42% of affected individuals. From 25 to 90% are prolactinomas. Pancreatic islet cell tumors occur in 60 to 70% of patients. Tumors are usually multicentric. Adenomas and adenomatous hyperplasia of the thyroid and adrenal glands may occur occasionally. Association with diffuse neuroendocrine tumors in the thymus, bronchi, and duodenopancreas is reported.