RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164087350 T1 van der Hoeve-Halbertsma-Waardenburg-Gualdi Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164087350 RD 2024/03/28 AB It is a rare genetic disorder characterized by a congenital defect involving skin pigmentation. The clinical features include a white forelock, vitiligo, partial or total heterochromic irides, pale blue eyes, hyperplastic broad high nasal root, lateral displacement of the medial canthi and lacrimal points, hyperplasia of the median portion of the eyebrows, and a unilateral deafness that is present in 15 to 20% of affected persons. The congenital deafness represents the most serious complication of this medical condition. Other clinical features include bone fragility as seen in osteogenesis imperfecta and Lobstein’s disease. Certain other structural abnormalities include short stature, hyperflexibility of joints, dental anomalies, laryngomalacia, and congenital heart defects.