RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164085591
T1 Spinocerebellar Ataxia (SCA): An Overview
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164085591
RD 2024/04/24
AB Spinocerebellar  ataxia  represents  a  group  of  slow  and  progressive  neurodegenerative  diseases  of  varying  inherited  degrees  of  rarity,  which  is  in  contrast  to  a  related  group  of  neurological  disorders  that  are  acquired  following  traumatic  injuries  or  other  external  agents.  The  development  of  ataxia  is  a  neurologic  sign  that  may  provide  a  clue  to  the  nature  of  the  underlying  disorder.  Interruption  of  afferent  and  efferent  connections  within  the  spinocerebellar  system  results  in  ataxic  gait,  scanning  dysarthria,  explosive  speech,  intention  tremor,  dysdiadochokinesia,  dysmetria,  and  abnormalities  of  eye  movements.  Many  variations  are  encountered  in  the  clinical  phenotype,  ranging  from  findings  of  pure  cerebellar  dysfunction  to  mixed  patterns  of  involvement  reflecting  extrapyramidal,  brain  stem,  and  cerebral  cortical  involvement.  Previously,  all  autosomal  dominant  ataxias  were  called  Marie  ataxia  and  all  autosomal  recessive  ataxias  were  called  Friedreich  ataxia.  They  may  be  present  at  almost  any  time  between  infancy  and  adulthood.