RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164078741 T1 Miller-Dieker Lissencephaly Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164078741 RD 2024/03/28 AB Malformation of the cerebral cortex with abnormal facies. Classic lissencephaly, also known as lissencephaly type I, is a brain malformation that may occur as an isolated abnormality (isolated lissencephaly sequence) or in association with certain underlying syndromes (eg, Miller-Dieker Syndrome, Norman-Roberts Syndrome). The condition is characterized by agyria or pachygyria of the gyri of the cerebral cortex, causing the brain’s surface to appear unusually smooth. In infants with classic lissencephaly, microcephaly is usually present. Other clinical features include seizures, severe or profound mental retardation, feeding difficulties, growth retardation, and impaired motor functions.