RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164077030
T1 Lissencephaly
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164077030
RD 2024/04/16
AB It  is  a  group  of  disorders  that  is  associated  with  incomplete  neuronal  migration  during  the  period  of  brain  development  at  9  to  24  weeks’  gestation.  It  is  characterized  by  the  absence  of  sulcation  of  the  cerebral  hemispheres  resulting  in  smooth  brain  surface  (absence  of  gyri).  The  name  comes  from  the  Greek  lissos  (smooth)  and  enkephale  (brain).  It  involves  the  whole  or  parts  of  the  surface  of  the  brain.  Clinically,  it  is  characterized  by  microcephalia,  severe  psychomotor  retardation,  failure  to  thrive,  intractable  seizures,  muscle  spasticity,  and  hypotonia.  The  onset  of  the  symptoms  varies  with  age  and  the  type  of  disorder.  Life  expectancy  is  often  shortened  due  to  respiratory  complications.