RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164070857
T1 Glanzmann’s Thrombasthenia
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164070857
RD 2024/04/18
AB Genetic  platelet  disorder  resulting  in  blood  clotting  disorder  and  hemorrhage.  The  disease  is  usually  diagnosed  in  young  ages  after  epistaxis  or  mucocutaneous  bleeding.  Complaints  such  as  easy  bruising,  muscle  hematomas,  hemarthrosis  gastrointestinal  bleeding,  menorrhagia,  and  hematuria  appear  in  further  stages  of  life.  This  medical  condition  is  associated  with  life-threatening  conditions  when  the  patient  is  exposed  to  stress  (eg,  surgery,  anesthesia).  It  is  an  extremely  rare  coagulopathy  disorder  in  which  the  platelets  contain  defective  or  low  levels  of  glycoprotein  IIb/IIIa  (GpIIb/IIIa),  which  is  a  receptor  for  fibrinogen.  As  a  result,  no  fibrinogen  bridging  of  platelets  to  other  platelets  can  occur,  and  the  bleeding  time  is  significantly  prolonged.