RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164070247 T1 Fragile X Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164070247 RD 2024/03/28 AB Most common form of X-linked mental retardation. Symptoms most often are limited to mild to moderate intellectual disability. Affects males more often and more severely than females. The clinical presentation is delayed development of speech and language by age 2. Physical features may include a long and narrow face, large ears, flexible fingers, and large testicles (macroorchidism) after puberty. In a third of people behavioral features include autism-like signs such as problems with social interactions and delayed speech. Hyperactivity is common and seizures occur in about 10%.