RT Book, Section A1 Bissonnette, Bruno A1 Luginbuehl, Igor A1 Engelhardt, Thomas SR Print(0) ID 1164067760 T1 Denys-Drash Syndrome T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259861789 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164067760 RD 2024/03/29 AB Denys-Drash Syndrome (DDS) has an onset during childhood and consists of the triad of congenital nephropathy (mesangial renal sclerosis), Wilms’ tumor (90% of affected individuals), and ambiguous genitalia (pseudohermaphroditism). Clinically, this medical condition is manifested with early Nephrotic Syndrome (edema, abdominal distention, and recurrent infections) that is usually present at birth but more between 1 and 2 years of age. It progresses to mesangial renal sclerosis, and ultimately end-stage renal failure—usually within the first 3 years of life.