RT Book, Section
A1 Bissonnette, Bruno
A1 Luginbuehl, Igor
A1 Engelhardt, Thomas
SR Print(0)
ID 1164066319
T1 Complex Disease/Deficiency: An Overview
T2 Syndromes: Rapid Recognition and Perioperative Implications, 2e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259861789
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1164066319
RD 2024/04/18
AB Complex  disorder  or  mitochondrial  disease  comprises  a  steadily  growing  group  of  genetically  and  clinically  heterogenous  enzyme-complex  defects  characterized  by  altered  energy  metabolism  (mitochondrial  oxidative  phosphorylation)  and  a  wide  range  of  neurological,  cardiac,  muscular,  and  endocrine  disorders.  The  system  of  oxidative  phosphorylation  is  composed  of  the  respiratory  chain  multi-protein  enzyme  complexes  I-V  and  the  two  electron-carriers  coenzyme  Q  (CoQ  or  ubiquinone)  and  cytochrome  c.  The  symptoms  associated  with  mitochondrial  disease  are  primarily  due  to  a  lack  of  energy  in  tissues  and  thus  organs  with  the  highest  energy  requirements  suffer  first  and  foremost.