RT Book, Section A1 Wetzel, Dawn M. A1 Phillips, Margaret A. A2 Brunton, Laurence L. A2 Hilal-Dandan, Randa A2 Knollmann, Björn C. SR Print(0) ID 1162544051 T1 Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259584732 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1162544051 RD 2024/03/28 AB Humans host a wide variety of protozoal parasites that can be transmitted by insect vectors, directly from other mammalian reservoirs, or from one person to another. The immune system plays a crucial role in protecting against the pathological consequences of many protozoal infections. Thus, opportunistic infections with protozoa are prominent in infants, individuals with cancer, transplant recipients, those receiving immunosuppressive drugs or extensive antibiotic therapy, and persons with advanced HIV infection. Because effective vaccines are unavailable, chemotherapy has been the only practical way to both treat infected individuals and reduce transmission. Satisfactory agents for treating important protozoal infections such as African trypanosomiasis (sleeping sickness) and chronic Chagas disease still are lacking. Many effective antiprotozoal drugs are toxic at therapeutic doses; this problem is exacerbated by increasing drug resistance. For a list of drugs and doses used to treat these diseases see Drugs for Parasitic Infections (2013).