RT Book, Section
A1 Mihic, S. John
A1 Koob, George F.
A1 Mayfield, Jody
A1 Harris, R. Adron
A2 Brunton, Laurence L.
A2 Hilal-Dandan, Randa
A2 Knollmann, Björn C.
SR Print(0)
ID 1162537223
T1 Ethanol
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259584732
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1162537223
RD 2024/04/16
AB Ethanol  (CH3CH2OH),  or  beverage  alcohol,  is  a  two-carbon  alcohol  that  directly  affects  many  different  types  of  neurochemical  systems  and  signaling  cascades  and  has  rewarding  and  addictive  properties.  It  is  the  oldest  recreational  drug  and  likely  contributes  to  more  morbidity,  mortality,  and  public  health  costs  than  all  illicit  drugs  combined.  The  current  Diagnostic  and  Statistical  Manual  of  Mental  Disorders  (DSM-5)  integrates  alcohol  abuse  and  alcohol  dependence  into  a  single  disorder  called  alcohol  use  disorder  (AUD),  with  mild,  moderate,  and  severe  subclassifications  (American  Psychiatric  Association,  2013).  This  chapter  presents  an  overview  of  the  effects  of  ethanol  on  various  physiological  systems,  then  focuses  on  the  mechanisms  of  ethanol’s  effects  in  the  CNS  as  the  basis  for  understanding  the  rewards,  disease  processes,  and  treatments  for  ethanol-related  conditions.