RT Book, Section A1 Hibbs, Ryan E. A1 Zambon, Alexander C. A2 Brunton, Laurence L. A2 Hilal-Dandan, Randa A2 Knollmann, Björn C. SR Print(0) ID 1162534252 T1 Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259584732 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1162534252 RD 2024/03/29 AB The nicotinic ACh receptor mediates neurotransmission postsynaptically at the neuromuscular junction and peripheral autonomic ganglia; in the CNS, it largely modulates release of neurotransmitters from presynaptic sites. The receptor is called the nicotinic ACh receptor because both the alkaloid nicotine and the neurotransmitter ACh can stimulate the receptor. Distinct subtypes of nicotinic receptors exist at the neuromuscular junction (Nm), in autonomic ganglia, and in the CNS (the neuronal form, Nn). The binding of ACh to the nicotinic ACh receptor initiates an EPP in muscle or an EPSP in peripheral ganglia by directly mediating cation influx into the postsynaptic cell (see Chapter 8).