RT Book, Section A1 Kofke, W. Andrew A1 Yandrawatthana, Sukanya A1 Kositratna, Guy A2 Longnecker, David E. A2 Mackey, Sean C. A2 Newman, Mark F. A2 Sandberg, Warren S. A2 Zapol, Warren M. SR Print(0) ID 1144136327 T1 Protection of the Central Nervous System in Surgical Patients T2 Anesthesiology, 3e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071848817 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1144136327 RD 2024/04/19 AB KEY POINTSThe incidence of perioperative stroke without predisposing factors is approximately 0.1%, but specific risk factors and procedures can increase the risk by 10-fold or more.Cerebrovascular reserve refers to the capability of the brain’s vasculature to dilate in order to compensate for perioperative physiologic stresses.Attention to maintenance of a normal physiologic milieu is the first principle of brain-oriented perioperative care.Fever kills vulnerable neurons, and hypothermia is protective in cases of cardiac arrest and possibly traumatic brain injury.Glycemic control, avoiding severe hyperglycemia, improves outcome after severe critical illness and probably optimizes neurologic outcome.Some anesthetics are neuroprotective, but some anesthetic drugs may have neurotoxic potential.