RT Book, Section A1 Benzon, Honorio T. A1 Jabri, Rasha S. A1 Zundert, Tom C. Van A2 Hadzic, Admir SR Print(0) ID 1141736664 T1 Neuraxial Anesthesia & Peripheral Nerve Blocks in Patients on Anticoagulants T2 Hadzic's Textbook of Regional Anesthesia and Acute Pain Management, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071717595 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1141736664 RD 2024/04/24 AB Intraspinal hematoma is a relatively rare condition resulting from a variety of causes. Traumatic causes include lumbar puncture and neuraxial anesthesia. It is more likely to occur in anticoagulated or thrombocytopenic patients, patients with neoplastic disease, or in those with liver disease or alcoholism. Approximately one-quarter to one-third of all cases are associated with anticoagulation therapy. The risk of intraspinal hematoma formation after administration of neuraxial anesthesia and analgesia is increased in patients who have received anticoagulant therapy or have a coagulation disorder.1 For this reason, neuraxial anesthesia is often contraindicated in the presence of a coagulopathy. Other risk factors for the development of epidural or spinal hematoma include technical difficulty (multiple attempts) in the performance of the neuraxial procedures due to anatomic abnormalities of the spine and multiple or bloody punctures.