RT Book, Section
A1 Pozek, John-Paul J.
A1 Beausang, David
A1 Segna, Kara G.
A1 Viscusi, Eugene R.
A2 Hadzic, Admir
SR Print(0)
ID 1141731176
T1 Controlled-Release Local Anesthetics
T2 Hadzic's Textbook of Regional Anesthesia and Acute Pain Management, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071717595
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1141731176
RD 2024/04/24
AB Local  anesthetics  (LAs)  are  among  the  most  useful  drugs  in  anesthesiology  practice  and  pain  management.  They  are  cornerstones  in  postoperative  pain  management  within  a  multimodal  analgesic  pathway  to  reduce  or  eliminate  opioids  and  their  resulting  adverse  events.  However,  currently  available  LAs  display  a  considerable  range  of  onset  and  duration  as  well  as  tolerability  across  a  wide  range  of  uses,  including  infiltration,  peripheral  blocks,  and  epidural  and  spinal  anesthesia.  Their  main  limitation  is  duration  of  action,  which  in  the  treatment  of  postoperative  pain  may  prevent  adequate  therapy  of  sufficient  duration.  For  that  reason,  continuous  catheter  infusion  systems  are  widely  used  but  introduce  challenges,  such  as  catheter  placement,  catheter  migration  and  maintenance,  and  the  burden  of  the  external  pump.  Therefore,  long-acting  LAs  with  predictable  onset,  delivery,  and  duration  of  action  would  be  a  near-ideal  solution.