RT Book, Section A1 Butterworth IV, John A2 Hadzic, Admir SR Print(0) ID 1141731075 T1 Clinical Pharmacology of Local Anesthetics T2 Hadzic's Textbook of Regional Anesthesia and Acute Pain Management, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071717595 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1141731075 RD 2024/03/28 AB Local and regional anesthesia and analgesia appear to be under going a renaissance, as judged by attendance at specialty meetings and substantial increase in research activity, as evidenced by growing number of scientific publications. In contrast to general anesthesia, in which the molecular mechanism remains the subject of speculation, the site at which local anesthetic (LA) drugs bind to produce nerve blocks has been cloned and mutated. This chapter focuses on mechanisms of anesthesia and toxicity, especially as knowledge of these mechanisms will assist the clinician in conducting safer and more effective regional anesthesia.